SARM stands for selective androgen receptor modulator.

As we get older our endurance, skeletal muscle and our overall strength deteriorates causing a hindrance of people’s ability to function normally. With the use of SARMs, your skeletal mass and strength  can be enhanced because it improves bone mineral density and has the ability to decrease body fat and increase a person’s lean body mass.

SARMs is a fresh start in the advancement of muscle pharmacology and it is for this reason that people are turning to SARMs as a daily supplement to their workout routines and maintaining a healthy lifestyle.

The Most Popular SARMs that are being used by athletes, bodybuilders and fitness lovers are the following:

  • LGD-4033 – a potent, non-steroidal bodybuilding supplement for enhancing lean muscle mass and reducing body fat
  • (MK-2866) – great for maintaining and increasing lean body mass and recomping
  • S4 – selective for bone tissue (mostly low virilization), aimed to cure osteoporosis and won’t produce the development of prostate and other secondary sexual organs
  • RAD140 – this is probably one of the most exciting SARMs, as well as the most current. In fact, aside from the muscle building effects seems to look like a possible cure for Alzheimer’s.

The Benefits of SARMs

SARMS is believed to have the capacity to employ the benefits of anabolic supplements while reducing the side effects of steroids.

  • Non-toxic (won’t cause liver damage)
  • Avoids bone loss
  • Decreases the threat of prostate problems in men without muscle mass loss
  • Won’t impede your HPTA
  • Similar effects with testosterone
  • No estrogen and conversion

Benefits for muscle builders, taking SARMS

  • Muscle loss prevention (during cutting period)
  • Lean muscle development
  • Improved strength
  • Faster injury recovery
  • Joint healing abilities
  • PCT use following anabolics

 

Overall Benefits for both men and women

Increased muscle strength

Increased Muscle size

Regulation of Libido

None or minimal side effects of SARMS

What’s great about SARMS is that its side effects are minimal, so you don’t have to worry about any negative effects. If you overdo it, however, some people may experience shut down or even gynecomastia if currently predisposed to it.

Be responsible, and in 99.9% of cases users will not have any side effects from the use of SARMs. Current research has so far agreed with that conclusion.

Stay Healthy

Author: Sarmsamerica admin

References:

Basaria, Shehzad, Lauren Collins, E. Lichar Dillon, Katie Orwoll, Thomas W. Storer, Renee Miciek, Jagadish Ulloor, Anqi Zhang, Richard Eder, Heather Zientek, Gilad Gordon, Syed Kazmi, Melinda Sheffield-Moore, and Shalender Bhasin. “The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men.” The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. Oxford University Press, Jan. 2013. Web. 22 Apr. 2017.

Coss, Christopher C., Amanda Jones, Michael L. Hancock, Mitchell S. Steiner, and James T. Dalton. “Selective androgen receptor modulators for the treatment of late onset male hypogonadism.” Asian Journal of Andrology. Medknow Publications & Media Pvt Ltd, 2014. Web. 22 Apr. 2017.

Dalton, J. T., R. P. Taylor, M. L. Mohler, and M. S. Steiner. “Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer.” Current opinion in supportive and palliative care. U.S. National Library of Medicine, Dec. 2013. Web. 22 Apr. 2017.

Dubois, Vanessa, Ioannis Simitsidellis, Michaël R. Laurent, Ferran Jardi, Philippa T. K. Saunders, Dirk Vanderschueren, and Frank Claessens. “Enobosarm (GTx-024) Modulates Adult Skeletal Muscle Mass Independently of the Androgen Receptor in the Satellite Cell Lineage.” Endocrinology. Oxford University Press, 01 Dec. 2015. Web. 22 Apr. 2017.

Dubois, V., I. Simitsidellis, M. R. Laurent, F. Jardi, P. T. Saunders, D. Vanderschueren, and F. Claessens. “Enobosarm (GTx-024) Modulates Adult Skeletal Muscle Mass Independently of the Androgen Receptor in the Satellite Cell Lineage.” Endocrinology. U.S. National Library of Medicine, Dec. 2015. Web. 22 Apr. 2017.

Jayaraman, Anusha et al. “Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats.” Endocrinology 155.4 (2014): 1398–1406. PMC. Web. 23 Apr. 2017.

Miller, Chris P., Maysoun Shomali, C. Richard Lyttle, Louis St. L. O’Dea, Hillary Herendeen, Kyla Gallacher, Dottie Paquin, Dennis R. Compton, Bishwabhusan Sahoo, Sean A. Kerrigan, Matthew S. Burge, Michael Nickels, Jennifer L. Green, John A. Katzenellenbogen, Alexei Tchesnokov, and Gary Hattersley. “Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140.” ACS Medicinal Chemistry Letters. American Chemical Society, 10 Feb. 2011. Web. 22 Apr. 2017. 

Mohler, M. L., C. E. Bohl, A. Jones, C. C. Coss, R. Narayanan, Y. He, D. J. Hwang, J. T. Dalton, and D. D. Miller. “Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.” Journal of medicinal chemistry. U.S. National Library of Medicine, 25 June 2009. Web. 22 Apr. 2017.

Narayanan, Ramesh, Sunjoo Ahn, Misty D. Cheney, Muralimohan Yepuru, Duane D. Miller, Mitchell S. Steiner, and James T. Dalton. “Selective Androgen Receptor Modulators (SARMs) Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial:Mesenchymal Stem Cell Signaling.” PLoS ONE. Public Library of Science, 2014. Web. 22 Apr. 2017.

 

 

 


 

SARM stands for selective androgen receptor modulator.

As we get older our endurance, skeletal muscle and our overall strength deteriorates causing a hindrance of people’s ability to function normally. With the use of SARMs, your skeletal mass and strength  can be enhanced because it improves bone mineral density and has the ability to decrease body fat and increase a person’s lean body mass.

SARMs is a fresh start in the advancement of muscle pharmacology and it is for this reason that people are turning to SARMs as a daily supplement to their workout routines and maintaining a healthy lifestyle.

The Most Popular SARMs that are being used by athletes, bodybuilders and fitness lovers are the following:

  • LGD-4033 – a potent, non-steroidal bodybuilding supplement for enhancing lean muscle mass and reducing body fat
  • (MK-2866) – great for maintaining and increasing lean body mass and recomping
  • S4 – selective for bone tissue (mostly low virilization), aimed to cure osteoporosis and won’t produce the development of prostate and other secondary sexual organs
  • RAD140 – this is probably one of the most exciting SARMs, as well as the most current. In fact, aside from the muscle building effects seems to look like a possible cure for Alzheimer’s.

The Benefits of SARMs

SARMS is believed to have the capacity to employ the benefits of anabolic supplements while reducing the side effects of steroids.

  • Non-toxic (won’t cause liver damage)
  • Avoids bone loss
  • Decreases the threat of prostate problems in men without muscle mass loss
  • Won’t impede your HPTA
  • Similar effects with testosterone
  • No estrogen and conversion

Benefits for muscle builders, taking SARMS

  • Muscle loss prevention (during cutting period)
  • Lean muscle development
  • Improved strength
  • Faster injury recovery
  • Joint healing abilities
  • PCT use following anabolics

 

Overall Benefits for both men and women

Increased muscle strength

Increased Muscle size

Regulation of Libido

None or minimal side effects of SARMS

What’s great about SARMS is that its side effects are minimal, so you don’t have to worry about any negative effects. If you overdo it, however, some people may experience shut down or even gynecomastia if currently predisposed to it.

Be responsible, and in 99.9% of cases users will not have any side effects from the use of SARMs. Current research has so far agreed with that conclusion.

Stay Healthy

Author: Sarmsamerica admin

References:

Basaria, Shehzad, Lauren Collins, E. Lichar Dillon, Katie Orwoll, Thomas W. Storer, Renee Miciek, Jagadish Ulloor, Anqi Zhang, Richard Eder, Heather Zientek, Gilad Gordon, Syed Kazmi, Melinda Sheffield-Moore, and Shalender Bhasin. “The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men.” The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. Oxford University Press, Jan. 2013. Web. 22 Apr. 2017.

Coss, Christopher C., Amanda Jones, Michael L. Hancock, Mitchell S. Steiner, and James T. Dalton. “Selective androgen receptor modulators for the treatment of late onset male hypogonadism.” Asian Journal of Andrology. Medknow Publications & Media Pvt Ltd, 2014. Web. 22 Apr. 2017.

Dalton, J. T., R. P. Taylor, M. L. Mohler, and M. S. Steiner. “Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer.” Current opinion in supportive and palliative care. U.S. National Library of Medicine, Dec. 2013. Web. 22 Apr. 2017.

Dubois, Vanessa, Ioannis Simitsidellis, Michaël R. Laurent, Ferran Jardi, Philippa T. K. Saunders, Dirk Vanderschueren, and Frank Claessens. “Enobosarm (GTx-024) Modulates Adult Skeletal Muscle Mass Independently of the Androgen Receptor in the Satellite Cell Lineage.” Endocrinology. Oxford University Press, 01 Dec. 2015. Web. 22 Apr. 2017.

Dubois, V., I. Simitsidellis, M. R. Laurent, F. Jardi, P. T. Saunders, D. Vanderschueren, and F. Claessens. “Enobosarm (GTx-024) Modulates Adult Skeletal Muscle Mass Independently of the Androgen Receptor in the Satellite Cell Lineage.” Endocrinology. U.S. National Library of Medicine, Dec. 2015. Web. 22 Apr. 2017.

Jayaraman, Anusha et al. “Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats.” Endocrinology 155.4 (2014): 1398–1406. PMC. Web. 23 Apr. 2017.

Miller, Chris P., Maysoun Shomali, C. Richard Lyttle, Louis St. L. O’Dea, Hillary Herendeen, Kyla Gallacher, Dottie Paquin, Dennis R. Compton, Bishwabhusan Sahoo, Sean A. Kerrigan, Matthew S. Burge, Michael Nickels, Jennifer L. Green, John A. Katzenellenbogen, Alexei Tchesnokov, and Gary Hattersley. “Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140.” ACS Medicinal Chemistry Letters. American Chemical Society, 10 Feb. 2011. Web. 22 Apr. 2017. 

Mohler, M. L., C. E. Bohl, A. Jones, C. C. Coss, R. Narayanan, Y. He, D. J. Hwang, J. T. Dalton, and D. D. Miller. “Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.” Journal of medicinal chemistry. U.S. National Library of Medicine, 25 June 2009. Web. 22 Apr. 2017.

Narayanan, Ramesh, Sunjoo Ahn, Misty D. Cheney, Muralimohan Yepuru, Duane D. Miller, Mitchell S. Steiner, and James T. Dalton. “Selective Androgen Receptor Modulators (SARMs) Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial:Mesenchymal Stem Cell Signaling.” PLoS ONE. Public Library of Science, 2014. Web. 22 Apr. 2017.

 

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2 comments

  • I am always skeptical of products that come out on the market and make false claims and Sarmsamerica team you have proven me wrong . Sarmsamerica team I have just read your blog about Sarms and I appreciate the way your Sarms team provides the information in a direct and concise manner. Sarms products are presented as they are. The article outlines Sarms products currently being sold by your team.and I have had the opportunity to check out the references the Sarmsamerica team provided in the above mentioned blog. The references collaborate the statements made about Sarms and this has had an influence in my purchasing your Sarms products. Given my nature as I stated I am skeptical but after 3 weeks of testing your Sarms products you have my vote of confidence. For those of you wondering why I took the time to write this….let’s just say when I discover something good I take the opportunity to say so. Sarmsamerica team I look forward to more info on your products and any Sarms advice you have to offer.

  • Very good sarms article and informative. I was think to buy sarmsamerica stuff so thanks for posting sarms articles. It is new products and major of people don’t know about sarms and how it works. I will try you mass building stack and I hope I will be able to put some muscle mass + It’s very good to know we can travel, take flights with sarms.. I can user for a long cycle with no interruption. Sarms America are the best !

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